The quantity of cocaine required to induce a toxic and potentially fatal reaction varies significantly between individuals. No specific amount guarantees an adverse outcome due to factors such as purity, route of administration, individual tolerance, and pre-existing health conditions. Estimating a definitive lethal dose is therefore unreliable and dangerous.
Understanding the unpredictable nature of cocaine toxicity is crucial for harm reduction and public health. Historical data and clinical studies reveal a wide range of fatal outcomes associated with different dosages. The stimulant effects of the drug can mask underlying health issues, increasing the risk of cardiac arrest, stroke, and respiratory failure, regardless of the quantity consumed. Risk is heightened by concurrent use of other substances, particularly alcohol or opioids.
